NanoMicroorganism Optical Detection System, NanoMODS®

Medcom Advance, S.A. is committed to NanoMODS® technology, which takes advantage of nanobiotechnology and Surface-Enhanced Raman Scattering (SERS) to allow rapid diagnosis of infections (Sepsis). NanoMODS ® aims to outperform competitors’ solutions in terms of analysis time, accuracy and number of identified microorganisms.

SERS has been stablished as an ultrasensitive analytical technique that can provide detection of even single molecules. Several direct and label-free applications have been developed in fields as biomedicine, pollutant monitoring or molecular and material characterization.

NanoMODS® has virtually unlimited multiplexing capability, associated with the unique spectra of molecules, the short detection times of the technique, and the small size of the necessary reagents. Thus, the method emerges as a revolutionary technique, being feasible to quantify multiple different types of bacteria in few minutes per milliliter of biological fluid (blood, urine, cerebrospinal fluid, etc.) in a single test.


Patents and Publications


Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles.
European Patent Office & United States Patent and Trademark Office, Patents granted. 

A method for detection of presence or absence of analytes in fluids and an optical detection system for carrying out the method:
European Patent Office, Patent granted.  United States Patent and Trademark Office, Patent granted.

Bernat Mir-Simon, Irene Reche-Perez, Luca Guerrini, Nicolas Pazos-Perez, and Ramon A. Alvarez-Puebla. Universal One-Pot and Scalable Synthesis of SERS Encoded Nanoparticles. Chemistry of materials, 2015, 27 (3), pp 950–958.

Nicolas Pazos-Perez, Elena Pazos, Carme Catala, Bernat Mir-Simon, Sara Gómez-de Pedro, Juan Sagales, Carlos Villanueva, Jordi Vila, Alex Soriano, F. Javier García de Abajo, Ramon A. Alvarez-Puebla. Ultrasensitive multiplex optical quantification of bacteria in large samples of biofluids. Scientific Reports, 6: 29014 (2016)

Carme Catala, Bernat Mir-Simon, Xiaotong Feng, Celia Cardozo, Nicolas Pazos-Perez, Elena Pazos, Sara Gómez-de Pedro, Luca Guerrini, Alex Soriano, Jordi Vila, Francec Marco, Eduardo Garcia-Rico, Ramon A. Alvarez-Puebla. Online SERS quantification of Staphylococcus aureus and the application to diagnostics in human fluids. Advanced Materials Technologies, 1 (8), 1600163 (2016)